In Round One, Fight! the stoic Ryu and his hod-headed friend, Ken, set out to investigate the murder of their martial arts master. Their search for Answers takes them to Japan where M. Bison, using his minions including Cammy, Vega, and Sagat, keeps a close eye on Ryu for reasons unknowns. This draws the attention of Hong Kong Interpol agent Chun-Li and US Special Ops officer Guile who each bear their own personal grudge against the evil Shadaloo syndicate.

This volume collects the main stories in the first six issues of the hit Street Fighter comic book series and well as the rare, hard-to-find issue #0.